46 下列何者是一氧化碳中毒（carbon monoxide poisoning）的病人，在腦部電腦斷層攝影可見到最典型的病灶？

橋腦腹部（basilar pons） 黑質（substantia nigra）

蒼白核（pallidum） 扣帶回（cingulate gyrus）

• Pathology in brain

• White matter demyelination
• Edema and necrosis bilaterally in the
• globus pallidus,
• caudate nucleus and
• cerebellum
• Characteristic finding is bilaterally symmetric low attenuation lesions in the globus palladi

Studies have indicated that CO may cause brain lipid peroxidation and leukocyte-mediated inflammatory changes in the brain, a process that may be inhibited by hyperbaric oxygen therapy. Following severe intoxication, patients display central nervous system (CNS) pathology, including white matter demyelination. This leads to edema and focal areas of necrosis, typically of the bilateral globus pallidus. Interestingly, the pallidus lesions, as well as the other lesions, are watershed area tissues with relatively low oxygen demand, suggesting elements of hypoperfusion and hypoxia.