1 有一染色體為47, XY, +21 之18 歲矮壯青年由母親陪同來門診，此青年希望結婚生小孩，下列何種

情況是較符合醫療知識及倫理之建議？

基於優生保健不應結婚生小孩 可以結婚生小孩

可以結婚但是可能不會生小孩 無法行房無法生小孩

ANS C

Infertility

There is infertility amongst both males and females with Down syndrome; males are usually unable to father children, while females demonstrate significantly lower rates of conception relative to unaffected individuals.^{[citation needed]} Women with DS are less fertile and often have difficulties with miscarriage, premature birth, and difficult labor. Without preimplantation genetic diagnosis, approximately half of the offspring of someone with Down syndrome also have the syndrome themselves.^[21] Men with DS are almost uniformly infertile, exhibiting defects in spermatogenesis.^[22] There have been only three recorded instances of males with Down syndrome fathering children