Monday, November 29, 2010

57
下列關於小兒麻痺病毒(Poliovirus)之敘述,何者為錯?
分類上屬於小RNA病毒科(Picornaviridae),包括三種血清型
其疫苗有沙克疫苗及沙賓疫苗,均為包含三種血清型之混合疫苗
感染後大部分人出現中樞神經症狀,少部分人為無症狀感染
麻痺性脊髓灰白質炎(paralytic poliomyelitis)主要是因為此病毒感染脊髓前角細胞(anterior horn cell)所致
C

In 95% of cases only a primary, transient presence of viremia (virus in the bloodstream) occurs, and the poliovirus infection isasymptomatic.

59
真菌細胞壁特有的成分是:
麥角醇 幾丁質 角質 醣苷類
B

幾丁質 CHITIN
麥角醇 ERGOSTEROL
醣苷類 GLYCOSIDE


63
下列何種自體免疫疾病,主要是由於自體免疫反應性T細胞所引起?
 自體免疫胰島素-依賴性糖尿病(autoimmune insulin-dependent diabetes mellitus)
全身性紅斑狼瘡(systemic lupus erythematosus)
重症肌無力(myasthenia gravis)
Grave氏病(Grave’s disease)
A


64
下列何者為器官特異性的自體免疫疾病?
 全身性紅斑狼瘡(systemic lupus erythematosus)
類風溼性關節炎(rheumatoid arthritis)
多發性硬化症(multiple sclerosis)
硬皮症(scleroderma)
C

66
下列何分子之缺陷不會影響到淋巴球的基因重組,但會使淋巴球的成熟受到阻礙?
IL-2 receptor γc chain RAG 1
RAG 2 DNA-dependent protein kinase
A

The Recombination Activating proteins RAG -1 and RAG-2 act together as a heterodimer in the initiation of the process of antigen receptor gene segment assembly. (Spanopoulou, 1996). These proteins are encoded by the Recombination Activating genes, which are found on human chromosome 11 (Shigeoka, 2002). The RAG genes are in very close proximity and consist of one exon (Janeway, 2001). These proteins are essential for proper formation and function of B cell and T cell receptors. (Janeway, 2001)These proteins are active only in the very early stages of lymphoid development as part of the V(D)J recombinase. These enzymes act together to effect somatic recombination. The RAG complex is responsible for initiating the recombination of the variable (V), diversity (D) and joining (J) gene segments of the receptor (Janeway 2001).




69
下列有關寄生蟲逃避寄主免疫反應的機制之描述,那一項不正確?
瘧疾原蟲(Plasmodium species)脫去circumsporozoite(CS)抗原
利什曼蟲(Leishmania species)引發寄主體內較高的Th1反應
錐型蟲(Trypanosomes)外表有變異醣蛋白(variant surface glycoprotein)
血吸蟲(Schistosomes)外表包覆著人類的ABO血型抗原
B


70
下列何者不是B細胞表面分子?
Igα和Igβ CD3 CD19和CD21 CD40
B

B LYMPHOCYTES, NO 3!!!!! B=2 NO 3




71
Lipopolysaccharide(LPS)是革蘭氏陰性細菌細胞壁的成分,會和白血球上的那個分子結合?
CD1 CD5 CD14 CD25
C


73
下列那種分子的配對組合(內皮細胞上的分子/白血球上的分子)會在發炎反應細胞遷移(cell migration)時發生?
MadCAM/α4β1
E-selectin/CD15s(sialyl-Lewis-X carbohydrate of CD15)
IL-8/CCR2
VCAM-1/LFA-1
B

74
下列那一種細胞不能呈獻(presenting)胜肽(peptide)抗原給輔助型T細胞(helper T cells)?
B細胞 嗜中性白血球(neutrophils)
巨噬細胞(macrophages) 樹狀突出細胞(dendritic cells
B

NEURTAL NGA SYA, NO PRESENTING !!!!

77
下列關於薑片蟲(Fasciolopsis buski)的敘述,何者正確?
為寄生在人體肝臟的巨大吸蟲
因食入淡水魚中的囊狀幼蟲(metacercaria)感染
嚴重感染時可能發生水腫和腹水現象
可以用「免疫診斷」來確認診斷
C
Fasciolopsiasis results from an infection by the trematode Fasciolopsis buski. [1] The largest intestinal fluke ofhumans (

AUQATIC PLANT: NOT FISH
INTESTINAL:NOT LIVER
Microscopic identification of eggs, or more rarely of the adult flukes, in the stool or vomitus is the basis of specific diagnosis.






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