Monday, November 15, 2010

3 下列有關主要組織相容性複合體(major histocompatibility)之敘述,何者錯誤?
CD4+ T細胞可辨認結合第二類MHC分子的胜肽
CD8+ T細胞為第二類MHC限制性
MHC分子的生理功能是將胜肽呈獻給T細胞
人類的MHC分子稱為人類白血球抗原(HLA)


ANS B

NameFunctionExpression
MHC class IEncodes non-identical pairs (heterodimers) of peptide-binding proteins, as well as antigen-processing molecules such as TAP and Tapasin.All nucleated cells. MHC class I proteins contain an α chain & β2-micro-globulin(not part of the MHC encoded by chromosome 15). They present antigen fragments to cytotoxic T-cells via the CD8 receptor on the cytotoxic T-cells and also bind inhibitory receptors on NK cells.
MHC class IIEncodes heterodimeric peptide-binding proteins and proteins that modulate antigen loading onto MHC class II proteins in the lysosomal compartment such as MHC II DM,MHC II DQ, MHC II DR, and MHC II DP.On most immune system cells, specifically on antigen-presenting cells. MHC class II proteins contain α & β chains and they present antigen fragments to T-helper cells by binding to the CD4 receptor on the T-helper cells.
MHC class IIIregionEncodes for other immune components, such as complement components (e.g., C2,C4, factor B) and some that encode cytokines (e.g., TNF-α) and also hsp.Variable (see below).

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