44 大腸桿菌中DNA 聚合酶（I, II, III）的特性如附表，在下列選項中找出各個聚合酶（X, Y, Z）的名稱：

X Y Z

3’ exonuclease yes yes yes

5’ exonuclease no no yes

Biological ․SOS DNA repair ․Replicative ․DNA repair

Function chain ․DNA primer

elongation excision

 X = polymerase I, Y = polymerase II, Z = polymerase III

 X = polymerase I, Y = polymerase III, Z = polymerase II

 X = polymerase II, Y = polymerase I, Z = polymerase III

 X = polymerase II, Y = polymerase III, Z = polymerase I

ans D

45 因核苷酸去除修復（nucleotide excision repair）系統發生變異時所引起的兩種疾病a 及b：a. Xeroderma

pigmentosum b. Cockayne’s syndrome，這兩種疾病的病徵為：I.皮膚對光影敏感，生長衰敗，神經

系統異常 II.人類遺傳疾病，可引起皮膚癌 III.可增加乳癌和卵巢癌的風險。請選出最合適的配對：

 a-I, b-II  a-II, b-I  a-III, b-II  a-I, b-III

ans B

cancer association is with XP

49 檸檬酸循環（Citric acid cycle）中那個酵素可催化FADH2 的產生？

異檸檬酸脫氫酶（Isocitrate dehydrogenase）

蘋果酸脫氫酶（Malate dehydrogenase）

α-酮戊二酸脫氫酶（α-Ketoglutarate dehydrogenase）

琥珀酸脫氫酶（Succinate dehydrogenase）

ans D

51 缺乏下列何種酵素，會讓新生兒使用Chloramphenicol 時造成“Gray baby＂？

 UDP-glucuronyl transferase  Cytochrome p-450

 Glutathione transferase  N-Acetyl transferase

ans A

Pathophysiology

Two pathophysiologic mechanisms are thought to play a role in the development of gray baby syndrome after exposure to the anti-microbial drug chloramphenicol. This condition is due to a lack of glucoronidation reactions occurring in the baby, thus leading to an accumulation of toxic chloramphenicol metabolites. :^[2]

1. The UDP-glucuronyl transferase enzyme system of infants, especially premature infants, is immature and incapable of metabolizing the excessive drug load.
2. Insufficient renal excretion of the unconjugated drug.

[edit]Clinical features

Toxic levels of chloramphenicol after 2–9 days result in:

• Vomiting
• Ashen gray color of the skin
• Limp body tone
• Hypotension (low blood pressure)
• Cyanosis blue discolouration of lips and skin.
• Hypothermia
• Cardiovascular collapse

[edit]

52 藥物在血漿中的濃度以“一次級的動力學＂下降，則表示：

只經由一種藥物的代謝途徑大部份在肝臟中代謝

藥物只存在血液循環內大約等於其半衰期

ans D

zero order is linear

64 下列藥物何者屬於Alkylating agent？

 Thioguanine  Busulfan  Bleomycin  Vincristine

ans B

67 有關fomivirsen 之敘述中，下列何者錯誤？

是一phosphorothioate oligonucleotide

主要作用為抑制病毒之DNA polymerase

可用於局部治療巨細胞病毒（CMV）引起之視網膜炎

有增加眼內壓之副作用

ans

B

Mechanism

It is an oligonucleotide^[1] that blocks translation of viral mRNA by binding to a coding segment of a key CMV gene. It was the firstantisense antiviral approved by the FDA.^[2]

70 Fluoxetine 與MAOI 併用不會產生下列何種副作用？

 tremor  sexual dysfunction  insomnia  constipation

ans D