Hereditary spherocytosis

in case like this

Mean corpuscular hemoglobin concentration

increase MCHC (more eiosinophilic) and osmotic fragility

MCHC is diminished ("hypochromic") in microcytic anemias, and normal ("normochromic") in macrocytic anemias (due to larger cell size, though the hemoglobin amount or MCH is high, the concentration remains normal). MCHC is elevated ("hyperchromic") in hereditary spherocytosis, sickle cell disease andhomozygous hemoglobin C disease.^[5]