62 T淋巴球及巨噬細胞在Mycobacterium leprae感染的兩種不同的型態中，有不同的反應，下列何者為是？

tuberculoid leprosy包括granulomas的形成，細菌數目較lepromatous leprosy為多

tuberculoid leprosy中T淋巴球產生細胞激素以IL-4, IL-5, IL-10為主

lepromatous leprosy中T淋巴球反應為正常，產生IL-2, IFN-γ, TNF-β等

lepromatous leprosy時細菌數目多，巨噬細胞中的細菌仍生長迅速

ANS D

WHO	Ridley-Jopling	ICD-10	MeSH	Description	Lepromintest	Immune target
Paucibacillary	tuberculoid ("TT"), borderline tuberculoid ("BT")	A30.1, A30.2	Tuberculoid	It is characterized by one or more hypopigmented skin macules and anaesthetic patches, where skin sensations are lost because of damaged peripheral nerves that have been attacked by the human host's immune cells.	Positive	bacillus (Th1)
Multibacillary	midborderline or borderline ("BB")	A30.3	Borderline	Borderline leprosy is of intermediate severity and is the most common form. Skin lesions resemble tuberculoid leprosy but are more numerous and irregular; large patches may affect a whole limb, and peripheral nerve involvement with weakness and loss of sensation is common. This type is unstable and may become more like lepromatous leprosy or may undergo a reversal reaction, becoming more like the tuberculoid form.
Multibacillary	borderline lepromatous ("BL"), and lepromatous ("LL")	A30.4, A30.5	Lepromatous	It is associated with symmetric skin lesions, nodules, plaques, thickened dermis, and frequent involvement of the nasal mucosa resulting in nasal congestion andepistaxis (nose bleeds) but typically detectable nerve damage is late.	Negative	plasmid inside bacillus (Th2)