40 下列何種酵素不會參與DNA複製（DNA replication）？

 DNA拓樸異構酶（DNA topoisomerase）

解螺旋酶（helicase）

單股DNA鍵結蛋白（single-stranded DNA binding protein）

依賴DNA的RNA聚合酶（DNA-dependent RNA polymerase）

d

41 癌症腫瘤細胞傾向進行無氧呼吸，下列關於無氧呼吸glucose代謝的敘述，何者錯誤？

產生ATP較少 產生lactate較多

產生acetyl-CoA較多 Krebs cycle參與的程度較低

C

產生acetyl-CoA較多

LESS A-COA: LESS GOING TO KREBS CYCLE

43 下列那種酵素活性高低會影響NADPH的形成以及glutathione的還原狀態？

Glucose 6-phosphate dehydrogenase Pyruvate dehydrogenase

Lactate dehydrogenase Alcohol dehydrogenase

A

Glucose-6-phosphate dehydrogenase (G6PD or G6PDH) is a cytosolic enzyme in thepentose phosphate pathway (see image), a metabolic pathway that supplies reducing energy to cells (such as erythrocytes) by maintaining the level of the co-enzyme nicotinamide adenine dinucleotide phosphate (NADPH). The NADPH in turn maintains the level of glutathione in these cells that helps protect the red blood cells against oxidative damage.

THIS IS THE PROBLEM ASSOCIATED WITH G6PD DEFICIENCY:

CONNECT THIS QUESTION TO THE RBC PROBLEM!!!!!

44 調控紅血球與O2親合力的重要因子為2,3-bisphosphoglycerate，它由下列那種代謝作用所提供？

酮體生成作用（ketogenesis） 糖解作用（glycolysis）

葡萄糖新生作用（gluconeogenesis） 五碳糖磷酸途徑（pentose phosphate pathway）

B