29 下列那一個胺基酸可以降解成fumarate?
Phenylalanine Alanine Cysteine Serine
BONUS
TYROSINE
ASPARTATE
PHENYLALANINE
REVIEW THE UREA CYCLE:
The urea cycle (also known as the ornithine cycle) is a cycle of biochemical reactions occurring in many animals that produces urea ((NH2)2CO) fromammonia (NH3)
Organisms that cannot easily and quickly remove ammonia usually have to convert it to some other substance, like urea or uric acid, which are much less toxic. Insufficiency of the urea cycle occurs in some genetic disorders (inborn errors of metabolism), and in liver failure. The result of liver failure is accumulation of nitrogenous waste, mainly ammonia, which leads to hepatic encephalopathy
Reactions
The urea cycle consists of five reactions: two mitochondrial and three cytosolic.
Step Reactants Products Catalyzed by Location 1 NH4+ + HCO3− + 2ATP carbamoyl phosphate + 2ADP + Pi CPS1 mitochondria 2 carbamoyl phosphate + ornithine citrulline + Pi OTC mitochondria 3 citrulline + aspartate + ATP argininosuccinate + AMP + PPi ASS cytosol 4 argininosuccinate Arg + fumarate ASL cytosol 5 Arg + H2O ornithine + urea ARG1 cytosol
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