Tuesday, November 23, 2010

29 下列那一個胺基酸可以降解成fumarate?
Phenylalanine Alanine Cysteine Serine
BONUS

TYROSINE
ASPARTATE
PHENYLALANINE

REVIEW THE UREA CYCLE:
The urea cycle (also known as the ornithine cycle) is a cycle of biochemical reactions occurring in many animals that produces urea ((NH2)2CO) fromammonia (NH3)

Organisms that cannot easily and quickly remove ammonia usually have to convert it to some other substance, like urea or uric acid, which are much less toxic. Insufficiency of the urea cycle occurs in some genetic disorders (inborn errors of metabolism), and in liver failure. The result of liver failure is accumulation of nitrogenous waste, mainly ammonia, which leads to hepatic encephalopathy

Reactions

The urea cycle consists of five reactions: two mitochondrial and three cytosolic.

Reactions of the urea cycle
StepReactantsProductsCatalyzed byLocation
1NH4+ + HCO3 + 2ATPcarbamoyl phosphate + 2ADP + PiCPS1mitochondria
2carbamoyl phosphate + ornithinecitrulline + PiOTCmitochondria
3citrulline + aspartate + ATPargininosuccinate + AMP + PPiASScytosol
4argininosuccinateArg + fumarateASLcytosol
5Arg + H2Oornithine + ureaARG1cytosol

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