59 主要兩類抑制麥角固醇合成有關之抗真菌藥物為何?
Allylamines及Azoles Polyenes及Azoles
Allylamines及Echinocandins Polyenes及Echinocandins
answer A
麥角固醇 = ergosterol!!!!
the allylamines group:
he two allylamines (naftifine and terbinafine) inhibit ergosterol synthesis at the level of squalene epoxidase
the polyenes group:
These drugs interact with sterols in cell membranes (ergosterol in fungal cells; cholesterol in human cells) to form channels through the membrane, causing the cells to become leaky (Fig. 76-2). The polyene antifungal agents include nystatin, amphotericin B, and pimaricin.
the azole group:
In general, the azole antifungal agents are thought to inhibit cytochrome P450-dependent enzymes involved in the biosynthesis of cell membrane sterols.
the Echinocandins group:
Echinocandins are antifungal drugs that inhibit the synthesis of glucan in the cell wall, probably vianoncompetitive inhibition of the enzyme 1,3-β glucan synthase[1][2] and are thus called penicillin of antifungals
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