59 主要兩類抑制麥角固醇合成有關之抗真菌藥物為何？

Allylamines及Azoles Polyenes及Azoles

Allylamines及Echinocandins Polyenes及Echinocandins

answer A

麥角固醇 = ergosterol!!!!

the allylamines group:

he two allylamines (naftifine and terbinafine) inhibit ergosterol synthesis at the level of squalene epoxidase

the polyenes group:

These drugs interact with sterols in cell membranes (ergosterol in fungal cells; cholesterol in human cells) to form channels through the membrane, causing the cells to become leaky (Fig. 76-2). The polyene antifungal agents include nystatin, amphotericin B, and pimaricin.

the azole group:

In general, the azole antifungal agents are thought to inhibit cytochrome P₄₅₀-dependent enzymes involved in the biosynthesis of cell membrane sterols.

the Echinocandins group:

Echinocandins are antifungal drugs that inhibit the synthesis of glucan in the cell wall, probably vianoncompetitive inhibition of the enzyme 1,3-β glucan synthase^[1][2] and are thus called penicillin of antifungals