Tuesday, July 26, 2011

Renal failure

Renal failure may develop both acutely and chronically. It is commonly due to hypercalcemia (see above). It may also be due to tubular damage from excretion of light chains, also calledBence Jones proteins, which can manifest as the Fanconi syndrome (type II renal tubular acidosis). Other causes include glomerular deposition of amyloid, hyperuricemia, recurrent infections (pyelonephritis), and local infiltration of tumor cells.


MULTIPLE MYELOMOA: HYPERCA - RENAL PROBLEM - BENCE JONES PROTEIN




Monday, July 25, 2011

Aspartate transaminase (AST), also called aspartate aminotransferase (AspAT/ASAT/AAT) or serum glutamic oxaloacetic transaminase (SGOT), is a pyridoxal phosphate (PLP)-dependent transaminase enzyme

NOTE THE PYRIDOXAL PHOSPHATE

palmitic acid has 16 C
beta oxidation will give 8acetylcoA,7 NADH and 7FADH2
8AcetylCoA will yield--->24 NADH+8FADH2+8GTP(kreb's cycle)
1 NADH yields 3 ATPs
1 FADH2 gives 2 ATPs
(7+24)=31NADH; ( 7 + 8 )=15 FADH2;8GTP
total ATP=31*3+15*2+8=131
2 ATPs r used to activate palmitate to palmitoyl coA==>net ATP=131-2 =129


Trimetaphan camsilate (INN) or trimethaphan camsylate (USAN), trade name Arfonad, is a drug that counteracts cholinergictransmission at the ganglion type of nicotinic receptors of the autonomic ganglia and therefore blocks both the sympathetic nervous system and the parasympathetic nervous system. It acts as a non-depolarizing competitive antagonist at the nicotinic acetylcholinereceptor, is short-acting, and is given intravenously.

Therapeutic uses

The therapeutic uses of trimetaphan are very limited due to the competition from newer drugs that are more selective in their actions and effects produced. It is occasionally used to treat a hypertensive crisis and dissecting aortic aneurysm, to treat pulmonary edema, and to reduce bleeding during neurosurgery.


Montelukast (trade names Singulair and Montelo-10) is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment ofasthma and to relieve symptoms of seasonal allergies.

Zileuton (trade name ZYFLO) is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation. Zileuton is used for the maintenance treatment of asthma.

METHOTREXATE: DIHYDROFOLATE REDUCTASE INHIBITOR

Fluorouracil (5-FU or f5U) (sold under the brand names Adrucil, Carac, Efudix, Efudex and Fluoroplex) is a drug that is a pyrimidine analog which is used in the treatment of cancer. It is a suicide inhibitor and works through irreversible inhibition of thymidylate synthase. It belongs to the family of drugs called antimetabolites. It is typically administered with leucovorin.

Cancers

PTEN is one of the most commonly lost tumor suppressors in human cancer. During tumor development, mutations and deletions of PTEN occur that inactivate its enzymatic activity leading to increased cell proliferation and reduced cell death. Frequent genetic inactivation of PTEN occurs in glioblastoma, endometrial cancer, and prostate cancer; and reduced expression is found in many other tumor types such as lung and breast cancer.


BRCA1 (play /ˈbrækə/;[1] breast cancer 1, early onset) is a human caretaker gene that produces a protein called breast cancer type 1 susceptibility protein
BRCA2 (Breast Cancer 2 susceptibility protein) is a protein that in humans is encoded by the BRCA2 gene


Ground glass hepatocyte

From Wikipedia, the free encyclopedia
Micrograph showing ground glass hepatocytes. H&E stain.

In liver pathology, a ground glass hepatocyte, abbreviated GGH, is a liver parenchymal cell with a flat hazy and uniformly dull appearing cytoplasm on light microscopy. The cytoplasm's granular homogeneous eosinophilic staining is caused by the presence of HBsAg.

The appearance is classically associated with abundant hepatitis B antigen in the endoplasmic reticulum, but may also be drug-induced.[1][2] In the context of hepatitis B, GGHs are only seen in chronic infections, i.e. they are not seen in acute hepatitis B.


NORMAL WEIGHT BRAIN ADULT: 1300 -1400 G


Myeloperoxidase

From Wikipedia, the free encyclopedia
edit
Myeloperoxidase

Myeloperoxidase drawn from PDB 1D7W.
Identifiers
SymbolsMPO;
External IDsOMIM: 606989 MGI: 97137 HomoloGene: 55450GeneCards: MPO Gene
EC number1.11.2.2
RNA expression pattern
PBB GE MPO 203948 s at tn.png
PBB GE MPO 203949 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez435317523
EnsemblENSG00000005381ENSMUSG00000009350
UniProtP05164Q571G0
RefSeq (mRNA)NM_000250.1NM_010824.2
RefSeq (protein)NP_000241.1NP_034954.2
Location (UCSC)Chr 17:
56.35 - 56.36 Mb
Chr 11:
87.61 - 87.62 Mb
PubMedsearch[1][2]

Myeloperoxidase (MPO) is a peroxidase enzyme (EC 1.11.1.7) most abundantly present in neutrophil granulocytes (a subtype ofwhite blood cells). It is a lysosomal protein stored in azurophilic granules of the neutrophil. MPO has a heme pigment, which causes its green color in secretions rich in neutrophils, such as pus and some forms of mucus.


Function

MPO produces hypochlorous acid (HOCl) from hydrogen peroxide (H2O2) and chloride anion (Cl-) (or the equivalent from a non-chlorine halide) during the neutrophil's respiratory burst. It requires heme as a cofactor. Furthermore, it oxidizes tyrosineto tyrosyl radical using hydrogen peroxide as an oxidizing agent.[2]

Hypochlorous acid and tyrosyl radical are cytotoxic, so they are used by the neutrophil to kill bacteria and other pathogens.

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note the location of superior gemellus
it is least effected when obstruction with superior gluteal artery


PUDENDAL NERVE
BranchDescription
Inferior anal nervesgiven off shortly after passing through the Greater sciatic foramen.
Perineal nervemore superficial terminal branch
Dorsal nerve of penis/Dorsal nerve of clitorisdeeper terminal branch, traveling into the deep perineal pouch
posterior labial nervesposterior labia


NOTE THAT THE URINARY BLADDER IS NOT INCLUDED HERE

NOTE THAT THE RECTUM IS SUPPLIED, SEE INFERIOR ANAL NERVE

The superior gluteal artery (gluteal artery) is the largest branch of the internal iliac artery, and appears to be the continuation of the posterior division of that vessel.

It is a short artery which runs backward between the lumbosacral trunk and the first sacral nerve, and, passing out of the pelvis above the upper border of the Piriformis, immediately divides into a superficial and a deep branch.

下列何者行經於腰薦神經幹與第一薦神經之間,再經由坐骨大孔到臀部?



The palatoglossus is the only muscle of the tongue that is not innervated by the hypoglossal nerve (CN XII). It is innervated by the Vagus nerve (CN X)



Stylohyoid muscle

BY FACIAL NERVE 7

Along with the other three muscles of mastication (temporalis, medial pterygoid and lateral pterygoid), the masseter is innervated by the mandibular division of the trigeminal nerve.



The vast majority of ectopic pregnancies implant in the Fallopian tube. Pregnancies can grow in the fimbrial end (5% of all ectopics), the ampullary section (80%), the isthmus (12%), and the cornual and interstitial part of the tube (2%)


NOTE : MOST COMMON SIT E IS AT THE AMPULLARY SECTION





NOTE THAT THE PANCREATIC BUDS WILL BECOME THE BODY AND UNCINATE PROCESS OF PANCREAS



NOTE THAT IN THE INTERVILLOUS SPACE: MOTHER'S BLOOD



FAVORITE QUESTION:

AT CONTRACTION

I BAND SHORTEN

A BAND CHANGE NOT


TETRACYCLINE TO 30 S

ERYTHROMYCIN TO 50 S

THE -MYCIN GROUP ARE THE MACROLIDES


Neuraminidases, also called sialidases, catalyze the hydrolysis of terminal sialic acid residues from the newly formed virions and from the host cell receptors

 NA 可以和此病毒之細胞受器(receptor),即唾液酸(sialic acid)結合 ----THIS IS WRONG: NO COMBINE


PICORNAVIRIDAE IS NAKED, NON ENVELOPE, POSITIVE STRAND RNA


Arenavirus diseases and vectors
Virus↓Disease↓Vector↓Distribution↓
Lymphocytic choriomeningitis virusLymphocytic choriomeningitisHouse mouse (Mus musculus)Worldwide
Lassa virusLassa feverNatal Multimammate Mouse (Mastomys natalensis)West Africa
Junin virusArgentine hemorrhagic feverDrylands Vesper Mouse (Calomys musculinus)Argentina
Machupo virusBolivian hemorrhagic feverLarge Vesper Mouse (Calomys callosus)Bolivia
Guanarito virusVenezuelan hemorrhagic feverShort-tailed Cane Mouse (Zygodontomys brevicauda)Venezuela
Sabiá virusBrazilian hemorrhagic feverUnknownBrazil
Tacaribe virusBat (Artibeus)Trinidad
Flexal virusInfluenza-like illnessRice rat (Oryzomys)Brazil
Whitewater Arroyo virusHemorrhagic feverWoodrat (Neotoma)Southwestern USA

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As an antifungal, ketoconazole is structurally similar to imidazole and interferes with the fungal synthesis of ergosterol, a constituent of fungalcell membranes, as well as certain enzymes.


INTERFERE WITH MEMBRANCE SYNTHESIS



Pneumocystis pneumonia (PCP) or pneumocystosis is a form of pneumonia, caused by the yeast-like fungus (which had previously been erroneously classified as a protozoan) Pneumocystis jirovecii.


THE MOST COMMON EUKARYOTIC CAUSE OF INFECTION!



A number of different flatworm parasites in the family Schistosomatidae are what cause swimmer’s itch.



Naegleria fowleri (pronounced /nəˈɡlɪəriə/, also known as "the brain-eating amoeba") is a free-living excavate form of protist typically found in warm bodies of fresh water, such as ponds, lakes, rivers, and hot springs. It is also found in soil, near warm water discharges of industrial plants, and minimally chlorinated swimming pools (there is no evidence of this organism living in ocean water) in an amoeboid or temporary flagellate stage. It belongs to a group called the Percolozoa or Heterolobosea. Although not a true amoeba, the organism is often referred to as an amoeba for convenience.


在患者的腦脊髓液中看到快速移動的阿米巴,將其滴入蒸餾水中數小時後,則可看到其轉變為具兩

根鞭毛的鞭毛蟲,此人最可能感染的寄生蟲是


Ketone bodies are three water-soluble compounds that are produced as by-products when fatty acids are broken down for energy in the liver and kidney. They are used as a source of energy in the heart and brain.


NOTE FATTY ACID, NOT THE GLUCOSE


Production

Ketone bodies are produced from acetyl-CoA (see ketogenesis) mainly in the mitochondrial matrix of hepatocytes when carbohydrates are so scarce that energy must be obtained from breaking down fatty acids. Because of the high level of acetyl CoA present in the cell, the pyruvate dehydrogenase complex is inhibited, whereas pyruvate carboxylase becomes activated. Thus, the oxaloacetate produced will entergluconeogenesis rather than the citric acid cycle, as the latter is also inhibited by the elevated level of NADH resulting from ß-oxidation of fatty acids. The excess acetyl-CoA is therefore rerouted to ketogenesis. Such a state in humans is referred to as the fasted state.

Acetone is produced by spontaneous decarboxylation of acetoacetate, yielding levels of acetone much lower than those of other ketone bodies. Acetone cannot be converted back to acetyl-CoA; it is instead metabolized (e.g., converted to glucose via pyruvate[5]), excreted in theurine, or (as a consequence of its high vapor pressure) exhaled. Acetone is responsible for the characteristic "fruity" odor of the breath of